1.1 PATHOLOGY
· Intestinal:
The trophozoites of E.histolytica have an
invasive capability
The parasite penetrates the depths of the colonic crypts
at separate locations.Usually unaccompanied by
inflammatory reaction.
With progressive involvement penetration of the
muscularis mucosa occurs.
Overlying surface epithelium (mucosa) is then breached
and typically circumscribed flask shaped ulcers are
formed which eventually become confluent and involve the
muscularis
The cecum is the most common site of involvement followed
by ascending colon and the recto-sigmoid.
On occasion, tissue reaction includes an exuberant,
fibroblastic and lymphocytic response known as ameboma.
Such lesions occur in 1-5% of cases of amoebic colitis
and may clinically present like adenocarcinoma.
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