Wednesday, April 11, 2012

ONCOLOGY 1



ONCOLOGY
1. DEFINITION
1.1 Oncology is a study of neoplastic disease.
 
Neoplasms are defined as a cell population showing excessive non-useful
multiplication and have proved non-responsive to normal control
mechanisms, within the organism.
1.2 Benign tumours are slow growing cell masses that do not
invade into surrounding tissues. They also do not spread to
distant sites by metastasis.
1.3 Besides benign tumours there are a number of pre-malignant
conditions recognised. These are :
* Leukoplakia in the oral mucosa
* Barrett's Columnar cell lined oesophagus
* Severe gastric dysplasia
* Ulcerative colitis
In all these conditions malignant cells may be present but they
have not invaded the basement membrane. These are the cases
described as carcinoma in-situ.
1.4 Malignant neoplasm show in addition the ability to interfere
with the function of normal tissue in the neighbourhood by local
invasion (an event achieved by adhesion to adjacent tissue and
release of collagenase) and they also have the ability to
interfere with the function of distant organs by metastasizing
through blood or through lymphatic stream. These tumours are
usually fatal.
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