Wednesday, June 27, 2012

ANESTHESIA INTRODUCTION



ANAESTHESIA
1. INTRODUCTION
Surgical treatment of disease requires gaining access to deeper
tissues through the skin.
* The skin being a sensitive organ, is well provided with
sensory nerves.
* Thus,it becomes important to interrupt the sensory
pathways of skin and deeper tissues (anaesthesia)if
surgical treatment is to be given.
* There are essentially two primary modes of rendering a
patient insensitive to pain while undergoing surgical
procedure:
- General anaesthesia (central nervous system depression)
- Regional anaesthesia (local anaesthetic agents).
2. PRE-ANAESTHETIC EVALUATION
1. A thorough clinical examination of the patient is essential
to establish the health status of the patient.
2. To detect the effects of the disease process for which he is
undergoing the surgical procedure.
3. To detect any inter-current disease that he/she might be
suffering from.
 
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Wednesday, June 20, 2012

ONCOLOY 11

10.2 PALLIATIVE SURGERY
In cases where the carcinoma has spread and radical surgery
cannot be done. Palliative surgery is undertaken to bypass an
obstruction without removing the tumour (colostomy) and in some
cases to relieve the pain fig.
The use of chemotherapy and radiotherapy in combination with
surgery in various TNM stagings and gradings is in practice to
improve treatment outcomes.

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Wednesday, June 13, 2012

ONCOLOGY 10 SURGERY

10. SURGICAL OPTIONS IN CARCINOMA
10.1 Curative Surgery
This is planned for those cases where the primary tumour is
confined to the organ and the involved lymph nodes and
intervening lymphatics can be removed in one continuity (en-
block).
This is also referred to as radical surgery. The GI Tract is
then reconstructed see fig above
Curative surgery for secondries or recurrance is also possible
with follow up with markers and practice of second look in
colonic surgery.
 
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Thursday, June 7, 2012

ONCOLOGY 9 tumor markers



SPECIFIC MARKERS                                      



9.1 Carcino embryonic antigen (CEA)



This  marker correlates well with the  presence of  carcinoma  in

the gastrintestinal tract especially mentioned in relation to  Ca

of  colon.   Na marker is available for oesophagus,  Stomach  and

pancreatic carcinoma.



Ovarian  CA  125  is  most  reliable  for  diagnosis  of  ovarian

carcinomas  Prostate carcinoma, Prostatic specific antigen  (PSA)

is useful marker for detecting prostate carcinoma



9.2 Hepatocellular Carcinoma



Serum  alpha feto protein (AFP) in 50-80% of patients with  liver

carcinoma, this marker is positive



Carcinoids 5 hydroxindole-acetic  acid (5HIRA)  is  useful  for

diagnosis and management of this tumour.
Fall in level of marker is indication of good response to treatment.

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