Tuesday, December 27, 2011

BURNS 6

BURNS CLINICAL
A partial thickness burn involves the outer layer of the skin and
may extend into the dermis.
This wound, commonly termed a second degree burn, is
characterized by blistering of the skin and is red, moist and
painful; sensation is intact.
The clinical importance of differentiating between these depths
of injury lies on the understanding that a superficial wound
heals with minimal cosmetic or functional defect in two weeks.
The healing occurs from the peripheral migration of cells, and out pouring
of cells from sweat glands and hair follicals.
The deep partial thickness wound, although it will heal given 3
week or more and there will be a defect in function and cosmetic
defect. In these cases skin grafting will improve results.
With burn of full thickness the wounds are leathery, white or
charred dry with loss of sensation.
Because all the epidermis is destroyed, these wounds can only
heal by migration of epidermis from the margins of the wound.
During the process of healing, contraction occurs; this decreases
the area that must be epithelialized but leads to a poor cosmetic
result and the healed wound is less resistant to trauma.
If the wound is adjacent to or involves a joint, the function of
the joint will be impaired.
Large full thickness wounds should be either excised and closed
primarily or grafted with the patient's skin to prevent
deformity.
Wounds however are often of mixed depth in such cases evaluation
of discrete areas may not define the depth of the overall wound.
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Tuesday, December 20, 2011

BURNS 5


RADIATION BURNS

Injury caused by exposure to ionizing radiation may be limited to
the  skin  but often is deep.

Because these wounds  do  not  heal well,  care  must  be taken to avoid  additional  damage  of  the tissue.

The vasculitis that is associated with these injuries  is usually a lifelong problem.

2.1 PATHOLOGY
The   area   subjected   to   heat   shows   cellular   swelling,
disintegrative  necrosis or coagulative necrosis  depending  upon
the degree of heat it has been subjected to.
- The  application  of  heat  to  the  body  tissues  results  in
  denaturing of proteins.
- It also results in inactivation of enzyme systems.
- It has been shown that oxygen consumption of skin is decreased. 
- There is also decrease in glucose utilization.
- These  process  are  depressed  in  direct  proportion  to  the
  increase in heat.

The  maximum  injury would be inflicted at the point  of  contact
(Fig.Above) and varying grades of injury would be inflicted towards
the periphery of this point of contact.

This  gradation effect would also be observable from the  surface
of  the skin to its depth.

The depth of burns is also related  to the temperature of the heated object and the period for which  it remains  in  contact  with the skin(deeper burns  will  occur  in unconcious  patients

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Tuesday, December 13, 2011

BURNS 4


INHALATION INJURY

Diagnosis of inhalation injury is difficult to make, a
presumptive diagnosis is made based on a history that is
consistent and signs and symptoms that are associated with injury
to the airway.
Any patient who sustains injury in a closed space and has burns
above the clavicle, singeing of nasal hair, hoarseness, or
carbonaceous sputum should be assumed to have sustained an
inhalation injury.
Elevated carboxy-hemoglobin levels will confirm exposure to carbon
monoxide, but are not diagnostic for injury to the lung.
Because the primary concern early after inhalation injury is
obstruction of the airway, the upper airway should be evaluated
immediately, usually in the emergency department.
Flexible bronchos-copy provides the opportunity to confirm the
diagnosis and initiate therapy.

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Tuesday, December 6, 2011

BURNS 3

 
SPECIAL BURNS

Chemical  burns cause denaturing of protein, and  disruption  of

cellular integrity.

The  degree of injury is dependent on the time of  exposure,  the
strength of the agent, and the solubility of the agent is tissue.

Alkali tends to penetrate deeper into tissues than does an acid.

One  exception  to this is hydrofluoric  acid,  which  penetrates
lipid  membranes  very readily. 

The  major concern is evaluting patients who  sustain  electrical
injuries is that the surface injury, which may appear similar  to
other  burn  injuries, is often not indicative of the  extent  of
injury.

In the local area of injury subcutaneous tissue, muscle and  bone
may be injured.

Electrical  current flows along the path of least resistance  and
therefore   will   pass   through   nerve   and   blood   vessels
preferentially and cause injury to these tissues.
 If the current passes through the torso of the patient, organ injury may result.

Injury of the heart is primarily associated with arrhythmia.

Injury of  the other viscera  including  the   pancreas   and
gastrointestinal tract have been reported.

Late sequelae have been reported to occur months or  even  years
after electrical injury.

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Friday, November 25, 2011

BURNS 2


Evaluation of the Patient
The  first examination of the patient with burn injury has to  be
complete and should focus on

-Airway, breathing and circulation.

-Evaluation  are  specific with regard to,  inhalation  injury  to
lungs

-Burn  injured patient may have multiple system injury and  should
examined for these.

We  shall  deal  primarily  with recent  thermal  burns  in  this
post, since this occur frequently and in passing touch upon the
important  features of chemical and electric burns in so  far  as
they affect the treatment.


Type of Injury
The  patho-physiology involved in the wounds of a patient  with  a
burn injury is basically the same regardless of the cause.
In the superficial area of injury, coagulative necrosis occurs. 
In  this zone protein is irreversibly denatured and cellular integrity  is

lost.

Adjacent  to this zone is the zone of stasis in which  tissue  is
viable  but subject to further necrosis as the wound evolves  due
oedema and inflammation.

A third zone has been recognized below the zone of stasis and  is
characterized as a zone of hyperemia.

The depth of the coagulative necrosis that occurs in burns  which
are  caused by scalding, flame, or contact with a hot  object  is
directly  related  to  the  temperature,  duration  of  exposure,
thickness  of  the tissue, and state of the blood supply  in  the
tissue

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Wednesday, November 16, 2011

BURNS 1

BURNS

1.  Intact human skin must be looked upon as a highly efficient
FUNCTIONING organ of the human body.

The complete unbroken skin envelop is ascribed four main
functions:
1.1   It is capable of maintaining the internal environment
      through limiting the loss of water and electrolytes from
      the body surface.
1.2   Provides very efficient barriers to invasion by bacteria on
      its surface and in the surrounding atmosphere.
1.3   It provides an efficient apparatus for maintenance of body
      temperature, both through direct radiation of heat through
      the vast vascular bed in the skin, and through evaporation of
      sweat from the surface of the skin.       
1.4   Through its vast surface sensory nerve network, provides  
      an apparatus for detecting injurious agents and withdrawing
      the part from their vicinity.

2.  A  burn is a combination of dis-integrative,and copulative
necrosis of skin, and deeper structures, brought about by  any  of
the causes listed below:

THERMAL
   a)  Dry heat (open fire)
   b)  Moist heat (steam + hot liquids)
   CHEMICALS (ACIDS + ALKALIES)
   ELECTRIC BURNS (TOUCHING LIVE ELECTRIC WIRES)
   FLASH BURNS (HIGH TEMPERATURE SHORT DURATION)
   LIGHTNING.
   ULTRA VIOLET RAYS.
   RADIATION BURNS

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Wednesday, November 9, 2011

TROPICAL DISEASE 21

6.3.3 INVESTIGATIO



TB GIT
- There is a mild anaemia in about 80% of patients. 
- Hypoalbuninaemia may be present. 
- The ESR is elevated in over 90%of patients. 
- There is a relative neutropaenia with a relative lymphocytosis in
about one-third of patients. 
- Tuberculin test is positive in over 90% of patients.

6.3.4 SURGICAL TREATMENT
With  modern antituberculous drugs complete cure and  improvement
of  symptoms  occurs  in about 90%  of  patients  with  abdominal
tuberculosis.  
Surgery   is  reserved  for  the   treatment   of
complications namely:
   *  Bowel OBSTRUCTION.
   *  Peforation of an ulcer with PERITONITIS or combined with
      FISTULA formation of adjoining loops.
   *  Massive HAEMORRHAGE. The presence of an ileo-caecal mass of
      uncertain origin is an additional indication

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Wednesday, November 2, 2011

TROPICAL DISEASE 20


T.B.
DIGESTIVE TRACT





6.3.2 CLINICAL FEATURES

The most frequent symptoms is abdominal pain.

- There may be accompanying weight loss, abdominal distension and

vomiting.

-  Another  group  of  patients may  present  with  weight  loss,

anorexia, diarrhoea and fever. 

-  The pain intensity depends upon the site, duration and  extent

of the lesion and the presence of complications.

-  It is most frequently present in the umbical region which  may

become generalised or localised to the right iliac fossa.

-  The pain is often colicky in nature with nausea  and  vomiting

and visible peristalsis with lesions like  stricture,hypertrophic

lesions or adhesions producing intestinal obstruction.

- Abdominal tenderness is frequently seen and can be elicited  in

two-thirds  of the patients, indicating extension of the  disease

to the peritoneum and lymph nodes.

-  A palpable mass, and visible peristalsis can be seen  in  over

one-third of the patients.

- The mass can be due to hypertrophic ileoceacal tuberculosis  or

enlargement  of  lymph nodes and matting of loops  of  the  small

bowel.

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Wednesday, October 26, 2011

TROPICAL DISEASE 19




6.3 GASTROINTESTINAL TUBERCULOSIS
Gastrointestinal tuberculosis constitute nearly 1 percent of  all hospital   admission  
and  11  percent   of   small   intestinal obstruction.
These figures are low if compared with the clinical experience of
Surgeons.
The   explanation   is  that  establishing   the   diagnosis   of
tuberculosis  by  histopathology or demonstration of  bacilli  is
difficult.

6.3.1 PATHOLOGY
The abdominal cavity may be affected with tuberculosis through;   
   *  Primary  infection  due to direct ingestion  of  tubercular
      bacillus
   *  Spread from tuberculosis from other parts of the body
   *  Spread from female genital tract
There are three types of lesions seen:
   *  Ulcerative
   *  Fibrotic
   *  Hyperplastic
On  histology  a  typical granuloma  is  seen  however  caseation
necrosis is not always present.
Identification of tubercle bacilli is rare.
A  granuloma may show central caseation surronded  by  epitheloid
and  Langhans giant cells there are also areas  with  lymphocytes
and plasma cells.

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Wednesday, October 19, 2011

TROPICAL DISEASE 18


TRANSMISSION 2




- The risk of transmission is increased when susceptible contacts

share the air for prolonged periods of time with a person who has

untreated pulmonary TB and who is coughing freely.

-  In individuals who become infected, infectious  particles  are

inhaled through the nose and mouth, are carried down the  airways

of  the  lungs,  and eventually reach the  small  air  sacs  (the

alveoli).

It is in the alveoli that infection usually begins and where  the

tubercle bacilli are initially able to multiply.

-  During the first few weeks after infection,  tubercle  bacilli

spread  unchallanged from the initial location in the  lungs,to  the

lymph  nodes, in the center of the chest, and then to other  parts

of the body by way of the bloodstream.

-  Tubercle  bacilli  can  reach  all  areas  of  the  body,  but

frequently   travel  to  certain  areas  that  are   particularly

susceptible to developing disease, such as the upper portions  of

the lungs,the kidneys, the brain, and bone.

-  Within 2 to 10 weeks, the body's immunologic response to  the

tubercle  bacilli  is  usually  sufficient  to  prevent   further

bacterial multiplication and spread. 

-  At this point an infected person will usually have a  positive

tuberculin skin test.

- For those who develop active TB, the lungs are the most  common

site of disease (in approximately 85 percent of all cases). 

- But disease may occur at any site in the body.

- Extrapulmonary disease may occur in the;

lymph nodes,

brain(causing TB meningitis),

kidney,

bones, or any other site.

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Wednesday, October 12, 2011

TROPICAL DESEASE 16


6. TUBERCULOSIS


- Tuberculosis is a bacterial infection with many manifestations
and wide distribution in the world.
- The lungs are most commonly affected, but lesions may also
occur in the kidney, bones, lymph nodes, or disseminated
throughout the body.

- The causative organism is Mycobacterium tuberculosis, a rod 2
to 4 um in length and 0.3 um in thickness, it " is acid fast".

- Tubercle bacilli are aerobes thus the organs affected are
vascular and relatively high in oxygen tension; two species of
tubercle bacilli cause the disorder M.tuberculosis and M.bovis.

6.1 TRANSMISSION

This communicable disease caused by Mycobacterium tuberculosis,
often called tubercle bacilli.
- Is spread person to person.
- Airborne infectious particles are produced when a person with
infectious TB of the lung or larynx forcefully exhales such as
when coughing, sneezing, speaking,or singing.

- These particles are dispersed in the local environment, remain
airborne, and can be inhaled by someone sharing the same air
space.

- TB is more easily transmitted in closed air spaces where
ventilation is poor.

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Wednesday, October 5, 2011

TROPICAL DISEASE 15


4.2 VISCERAL LEISHMANIASIS (KALA-AZAR)

The causitive organism is L Donovani also transmitted by a

sandfly.

The prasite is transported by lymphatic to lymph nodes

and viscera.

Some control of the disease has occured through DDT

and antimalaria programmes.

It still persists in Assam, Bihar,West Bengal, Nepal and Sikkim.

4.2.1 Clinical

In the early stage the patient suffers from intermittant fever

and anaemia.

In later stages there is hepatosplenomegaly.

Bone marrow smears slow L. Donovani.

The patients respond to pentavalant antimony therapy.

TREATMENT

The disorder can be treated with stibogluconate.

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Wednesday, September 28, 2011

TROPICAL DESEAESE



Tropical disease 14




4. Leishmaniasis (Oriental Sore)



The causitive organism is L. tropica or Braziliensia in the west.


The organism is transmitted by a sandfly. The intermediate host


are dogs and rodents.



The disease occurs in dessert areas of India, Pakistan and the


middle east. With the eradication of sandflies with use of DDT


the incidene has been markedly reduced


4.1 CLINICAL


The disease occurs on exposed areas of the face or arms, a small


Indurated pappule if untreated breaks down resulting as a


persistant ulcer.


The lesion does respond to pentavalent


antimony therapy.


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Wednesday, September 21, 2011

TROPICAL DISEASE 13


HYDATID DESEASE


3.5 TREATMENT
- Thio bendazole can be used for treatment (50mg/kg/day),
albendazole better absorbed so a lower dose is effective 4 tabs
of 200 mg. daily for 28 days.
- Surgical excision of cyst wall (laminated and germinal) layers is
the standard treatment, the cyst is treated at the time of
operation with hypertonic fluid to kill all scolices.(Fig.8.7)
- Medical therapy with mebendazole is only considered in those
where surgical treatment is contraindicated.

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Wednesday, September 14, 2011

TROPICAL DESEASE 12


3.2 PREVENTION
1. Use of safe water, ponds may be contaminated
2. All domestic dogs be de-wormed

3.3 CLINICAL FEATURES
- The cysts in the liver and other organs (lungs muscles or bones)
can remain silent for long periods.
- Large cysts in the liver can cause a dull pain because of their
size.
- Infection and rupture can cause pain, bring on symptoms related
to these complcations.

3.4 DIAGNOSIS
* An X-ray may show a calcified cyst
* An intradermal skin test (Casoni's) to hydatid fluid is
positive in 70% of cases
* An indirect haemagglutination test is more dependable
* Ultrasound scan may demonstrate this cyst and its contents
in greater detail
· An ELISA test is helpful for mass screening of the population


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