PATHO-PHYSIOLOGY 1
The permeability of the capillary bed in the burn area is
increased and a protein rich filtrate passes into the
interstitial space in the burnt area.
This is because of histamine release.
Thromboxane A and cytokinins are also implicated.
Activation of the immune system also increases microvascular permeability.
* The rate of loss of fluid is most rapid in the first 8 hours
and continues till 48 hours.
* The fluid lost is of the same electeolytic composition as
plasma, but the protein content is about half that of plasma.
* From the third day fluid reabsorbtion starts.
* Thus in the first 48 hours there is a rise in protein
concentration in the plasma.
- In untreated cases this may lead to a massive shift of fluid
from the cells to extracellular space.
- This may lead to irreversible damage to renal tissue if not
treated early.
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