Wednesday, July 27, 2011

TROPICAL DISEASE 4




AMEBIASIS



COMPLICATIONS & DIAGNOSIS






4. Haemorrhage :
Amebic ulceration is rarely complicated by bleeding which may
often be severe and may require blood transfusion.Surgery may be
required.

5. Appendicitis:
Amebic ulcers have been demonstrated in appendices removed at
surgery; they are often associated with amebic colitis in other
parts of the bowel and perforation of the appendix can occur.

1.4 DIAGNOSIS
* Stool examination is a rapid and useful method.
However, demonstration of an amebic form does not necessarily
indicate that the symptoms are related.

* A sigmoidoscopy, and latex agglutination are the most
reliable tests.
* In symptomatic intestinal amebiasis, 70-90% are positive.
In the commensal state a lower percentage are positive.
However, circulating antibodies may persist for years.
Therefore, in endemic areas, a positive result does not
mean a currently active infection.
* Colonscopy may also be necessary for the diagnosis.
Treatment
* Therapeutic drug trial of an antiamebic drugs may be
necessary.
Most drugs that eliminate cysts or trophozoites from the gut do
not destroy tissue invading trophozoites.
Thus it is logical to combine a luminal amebicide and a tissue amebicide.
Where surgical complication is suspected, therapy should be started
without awaiting confirmation of diagnosis with parenteral
metronidozole, or in young patients with emetine and surgery
carried out urgently.

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