Tuesday, February 25, 2014

LIVER BILIARY TRACT 10 Atreasia


CONGENITAL BILIARY ATRESIA

Congenital  atresia  of the extrahepatic bile ducts is  the  most
common  cause of prolonged obstructive jaundice in  the  neonatal
period.

INCIDENCE

Biliary atresia occurs once in every 20,000 to 30,000 births.

PATHOLOGY

Failure  of  recanalization  of the ducts which  have  no  lumen.  
Coexistence of atresia of the extrahepatic and entrahepatic ducts
supports  the  belief  that a development anomaly  is  the  basic
defect.

The  procedure  is an attempt to reduce pressure  the  esophageal
veins by :

*   Devasularestion,  the  vessal  supplying  the  upper  greater
    curvature  (spleic bronchea) and the lesser  currature  (left
    gastric branches) are ligated
*   Shunt procedures like a spleno-renal anastamosis or an end to
    side porto-caval an mesenteric vein and canal anastomosis can
    also reduce pressure.

TREATMENT

Surgical  operation to expolore the fibrous tissues at the  Porta
Hepatis  and an anastomosis of bile channels with  an  intestinal
loop provides an outlet for the bile.

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Tuesday, February 18, 2014

LIVER & BILIARY TRACT 9 Portal hypertension treatment



PATHOLOGY

The collateral channesl that open up are:

*  The  coronary  veins that connect the  azygos  and  hemiazygos
   veins  (SV) with the oesophageal veins (PS) which are  dilated
   due to the increased pressure.

*  The  superior  hemorrhoidal veins (PS) that connect  with  the
   middle and inferior hemorrhoid veins (SV)

*  Umbilical (PS) and paraumbilical veins (SV) giving rise to the
   caput medusa.

*  Retroperitoneal veins.

OESOPHAGEO-GASTRIC VARICES

The  increase in pressure causes a dilatation of  the  submucosal
veins.

*  Later,  the mucosa atrophies and the wall of the  veins  forms
   the inner lining of the oesophagus.

*  The veins of the fundus of the stomach may also be involved.

*  Rupture  of these vessels can occur at any time  resulting  in
   serious manifestation of haematemesis.



TREATMENT

Treatment is directed at prompt control of the bleeding by :

*  Ballon tamponade with Sengstaken Blakmore tube Fig. above

*  Sclerotherapy of the bleeding veins

    5-6  cc  of  selorosant (Ethanomoline 5%) into  each  of  the
    venous  columns  a fibroptic gastoscope is required  and  the
    columns  are  injected above  the  gastroesophageal  junction
    other   sclerosants   used  are  absolute   alcohols   sodium
    morrhuate.

*  Surgical  treatment  attempts to reduce pressure by  a  porto-
   caval shunt operation or
   Splenic vein can be joined to the renal vein

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Tuesday, February 11, 2014

LIVER & BILIARY TRACT 8 Portal hypertension etioplogy pathopysiology


9. PORTAL HYPERTENSION

Portal hypertension may result from disease of the liver  leading
to  intrahepatic  obstruction or an obstruction to  the  flow  of
blood in the extrahepatic portal system

As  a  result,  abnormal channels of  communication  between  the
portal  system (PS) and systemic veins (SV) open up and a  common
site are the oesophageal veins Fig. above

ETIOLOGY

The majority of cases are due to intrahepatic obstructions  (90%)
and the disorders include:

*  Nutritional cirrhosis (commonest)
*  Postnecrotic cirrhosis and
*  Biliary cirrhosis

PATHOPHYSIOLOGY

The normal pressure is less than 300 mm of water and this can  be
measured by introduction of a cannula into portal tributaries and
shows  an  elevation.   There is in addition,  an  elevation  of
splenic pulp pressure.

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Wednesday, February 5, 2014

LIVER BILIARY TRACT 7 Tumours



8. LIVER TUMOUR

8.1 Benign

8.1.1 Adenoma

This  is a rare tumour usually seen as an incidental  finding  on
scan or laporatomy

TREATMENT

The  tumour should be removed if there is  uncertaininty  regards
diagnosis.

8.1.2 CAVERNOUS HAEMONGIOMA

This  is  the commonest tumour seen at autopsy as  an  incidental
finding.  They are silent, soft and spongy

TREATMENT

It is difficult

8.2 MALIGNANT HEPATOCELLULAR CARCINOMA

This  carcinoma  is  associated  with  cirrhosis  and  occurs  in
population where there is an association with large reservior  of
Hepatitis B carrier.

8.2.1 LIVER METASTASIS

These  are met with most often in cases where the primary  lesion
is in the gastro-intestinal tract, breast or lungs.


TREATMENT

Resection of single metastasis can be planned.

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