PHYSIOLOGY
EXOCRINE PANCREATIC JUICE
The
gland produces 1500
to 2500 ml/day
of the colourless
pancreatic juice.
*
With a pH of 8.0 to 8.3 and
*
It is isotonic
*
It contains
- amylolytic
- proteolytic and
- lipolytic enzymes that act at
an optimal pH greater than 7
*
Lipase splits fat into glycerol and fatty acids in presence of
bile salts.
Pancreatic Secretion
The exocrine function of the
pancreas represents the secretion of proenzymes required for the degestion of
carbohydrate proteins and fats as well as bicarbonate which causes the
duodental luminal fluid to have a pH near 8.0.
The proteolytic, amylolytic,
lipolytic, and mucolytic enzymes are secreted from the pancreas as proenzmes.
They are activated in the lumen, duodenum, and jejunm by the active form of the
enzymes itself as well by enterokinase, produced by the brush border membrane
of the duodenal and jejunal enterocytes.
The volume of pancreatic
secretion is nearly 1 L/day.
Pancreatic juice is isotonic
with plasma at all rates of secretion.
The acinar cell has receptors
for several secretagogue agonists: acetylcholine, gastrin CCKB, substance P,
and secretin/VIP
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