IMMUNE (IDIOPATHIC) THROMBOCYTOPENIC
PURPURA (ITP)
The syndrome is characterised by :
*
A reduced number of platelets in the peripheral blood
*
Abundance of megakaryocytes in the bone marrow
*
Shortened platelet life span and
*
An immunologic pathogenesis
*
Indirect evidence is presence of
an antiplatelet factor IgG
antibody in the plasma
*
It can be demonstrated that platelets coated with the antibody
are being selectively sequestered in the spleen
*
The major site of cell destruction can also be in the liver
The acute form is prominent in male
children under the age of ten
with
a history of antecedent
viral or bacterial
infection.
Idiopathic thrombocytopenic purpurra
occurring in the absence of
viral infection and in young adults
has a female : male ratio of
3:1.
Clinical manifestations include :
*
Petechiae
*
Eccymoses
*
Epistaxis
*
Bleeding gums
*
Vaginal bleeding
*
Gastrointestinal bleeding
*
Hematuria
Treatment splenectomy may be helpful
in some cases.
Any questions be sent p drmmkapur@gmail.com
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