Wednesday, October 2, 2013

STOMACH & DUODENUM 2 lymphatics cell variety & function


1.2 LYMPHATIC DRAINAGE

The  lymphatics follow the arteries and thus the lymph  from  the
upper lesser currature flows to the left gastric and  paracardial
lymphnodes.   Similarly, the antral vessal from lesser  curvature
flow  to the right gastric and suprapancreatic  lymphnodes.   The
greater curvature drains into gastroenpiploic artery lymph  nodes
(Rt  +  Lt).  This knowledge helps to predict  the  direction  of
spread  if  the  site of a tumour is know.  This  also  helps  to
define  the minimum limits of surgery required so as  the  tumour
draining lymph nodes and the lymphatics.

1.3  The parasympathetic supply is through the vagus  nerves  and
stimulates motility and secretion of acid and pepsin (fig16.2a).

1.4  The  wall  of  the stomach has  four  distinct  layers  from
outwards -  the serosa (visceral peritoneum)
-  muscle
-  submucosa
-  and mucosa the inner most layer.
The mucosal structure varies, the fundus has (fig above)
- parietal cells that secrete acid and intrinsic factor.
- Chief cells that secrete pepsinogen
The antral mucosa has
- G cells that secrete gastrin
- Delta cells that secrete somatostatin.
There are in addition in the mucosa
- Goblet cells that secrete mucus.
- Mast cells that store heparin and histamine

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