Tuesday, October 29, 2013

PEPTIC ULCER 1


SECRETIN
This hormone is released from the proximal duodenal mucosa into
the blood stream.
- The hormones causes a secretion from the pancreas of bicarbonate,
a similar increase of bicarbonate is also caused in the bile.
- Pepsinogen secretion of gastric mucosa is increased.
- Gastrin and acid secretion from stomach is decreased.
Secretin
Secretin is the hormone that is the main stimulant of bicarbonate and water secretion from the centroacinar cells lining the proximal pancreatic ducts.
Secretin is produced by the S cell in the duodenum and jejunum. This action is stimulated of the release of secretion when the luminal pH of 4.5 or less. Circulating secretin stimulates bicarbonate-rich fluid from the centroacinar cells of the pancreas and from Brunner’s glands in the duodenum.
PEPTIC ULCER
A peptic ulcer is an erosion (break down) of the mucosa of the
gastrointestinal tract located adjacent to acid-secreting cells
and it occurs in the;
*  Lower oesophagus (Barrett's Ulcer)
*  The antrum of the stomach(Gastric ulcer)
*  Duodenum first part(Duodenal ulcer)
*  The jejunum at the margin of a gastrojejunostomy
*  In the ileum at the outlet of a Meckel's diverticulum  bearing
   aberrant gastric mucosa
Duodenal and Gastric ulcer are types of ulcers most often
seen in practice.

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